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Professor
UTHSC College of Dentistry
University of Tennessee Health Science Center
Dr. Rajasingh Johnson's research profile indicates a strong focus on regenerative medicine, particularly in the context of repairing the heart, lung, and oral tissues. Here's a summary of his research background and interests:
Current Position:
• Professor in the Department of Bioscience Research at the University of Tennessee Health Science Center, Memphis.
• Secondary appointments at the Department of Medicine-Cardiology and Department of Microbiology, Immunology & Biochemistry at UTHSC.
Regenerative Medicine: Focused on developing novel strategies to enhance the therapeutic efficacy of stem cells in regenerative applications.
Tissue Repair: Special interest in repairing heart, lung, and oral tissues through advanced cell- and exosome-based approaches.
Somatic Cell Reprogramming: Employing a safe, non-integrating method using mRNA encoding pluripotency factors to reprogram normal and patient-derived somatic cells into induced pluripotent stem cells (iPSCs).
Cell Differentiation: Directing iPSCs to differentiate into various specialized cell types, including cardiomyocytes, neuronal progenitor cells, odontoblasts, osteoblasts, and mesenchymal stem cells.
Therapeutic Applications: Exploring the potential of iPSC-derived cells and exosomes as therapeutic tools for the treatment of myocardial infarction and other degenerative
Overall, Dr. Johnson's research seems to bridge molecular biology, stem cell biology, and regenerative medicine with a specific emphasis on translational applications for treating cardiovascular and oral diseases. His work on reprogramming and differentiating cells, particularly using a safe mRNA-based approach, suggests a commitment to advancing therapeutic strategies for tissue repair and regeneration. The exploration of iPSC-derived cells and exosomes as potential treatments reflects the cutting-edge nature of his research in the field of regenerative medicine.