4 - Efficacy and Safety of Intranasal Dexmedetomidine in Pediatric Dental Sedation

Abstract:

Purpose: This multi-year, single-site, prospective clinical study was completed to examine the effectiveness and safety of intranasal dexmedetomidine (DEX), oral midazolam (MID), and oral midazolam with oral hydroxyzine (MIDHYX), in achieving moderate sedation for pediatric dental treatment.

Methods: Children 3-6 years of age, who were ASA I or II, with at least one quadrant of dental treatment needs and no prior history of dental sedations, were recruited. Three drug modalities were utilized: intranasal dexmedetomidine (DEX), oral midazolam (MID), or oral midazolam with oral hydroxyzine (MIDHYD), all with nitrous oxide. Dental treatments performed included composite restorations, stainless steel crowns, pulpal therapy, extractions, and sealants. A standardized scale, modified from the University of Michigan Sedation Scale, and the American Academy of Pediatric Dentistry Sedation scale were used to evaluate the effectiveness based on sedation level and behavior respectively. Primary outcomes were to assess the safety and efficacy of DEX as a sedation modality and to compare the behavior and sedation levels of patients receiving each respective modality. Descriptive statistics were generated.

Results: Final Data Pending

Conclusion: Preliminary data suggests that using intranasal dexmedetomidine as a medication for pediatric dental sedation can be part of a safe and effective modality in achieving successful levels of sedation and improving behavior during in-office dental treatment.

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