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Faculty
University of Louisville
University of Louisville
My research focuses on the molecular and systems-level mechanisms governing host–microbiome interactions in chronic inflammatory diseases, with particular emphasis on how microbial communities reprogram innate immune signaling. To address these questions, I integrate interdisciplinary approaches combining molecular genetics, biochemical and spectroscopic techniques, systems-level omics analyses (including transcriptomics and metabolomics), immunological models, and quantitative modeling. By integrating mechanistic immunology with systems-level approaches, we aim to identify fundamental principles governing microbiome-driven immune signaling and the persistence of inflammatory states. Ultimately, this work seeks to uncover novel therapeutic targets for controlling chronic infections and inflammation-associated diseases.