241 - Oral Manifestations of Coffin-Siris Syndrome: A Case Report

Saturday, May 23, 2026

10:45 AM - 11:00 AM PST

Has Audio

Presenting Author(s)

Abagael Bridwell, DDS

PGY-2
Case Western Reserve University — UH Rainbow Babies and Children’s Hospital, Cleveland, OH
Case Western Reserve University
Cleveland, Ohio, United States

Research Mentor(s)

YA

Ying An, DDS, PhD

CWRU and UH Rainbow Babies and Children's Hospital
Cleveland, Ohio, United States

Program Director(s)

MF

Margaret Ferretti, DMD, MPH

Assistant Professor
CWRU and UH Rainbow Babies and Children's Hospital
Cleveland, Ohio, United States

Abstract:
Oral Manifestations of Coffin-Siris Syndrome: A Case Report
Bridwell A, An Y, Ferretti M
Case Western Reserve University, Cleveland, OH

Coffin-Siris syndrome is a rare genetic disorder characterized by developmental delay, craniofacial anomalies, and variable systemic involvement. This report aims to describe the oral manifestations and dental management considerations observed in an adolescent patient with Coffin-Siris syndrome. This case report presents a 17-year-old male with Coffin-Siris syndrome who underwent comprehensive dental rehabilitation under general anesthesia in 2025. Clinical examination revealed numerous over-retained primary teeth, delayed eruption of permanent teeth, and severe generalized attrition approaching the pulp. The patient’s dental age was significantly delayed relative to his chronological age, with multiple permanent teeth unerupted and radiographic findings suggesting a guarded prognosis for future eruption. Management included extraction of non-restorable teeth and restorative treatment of remaining dentition. This case highlights the importance of recognizing dental anomalies associated with Coffin-Siris syndrome and emphasizes the need for early dental assessment and long-term monitoring in affected individuals.

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