149 - Clinical Outcomes of Curodont Application on Incipient Caries of Permanent Teeth

Friday, May 22, 2026

2:40 PM - 2:55 PM PST

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Presenting Author(s)

Carleen Tse-Goldstein, Pediatric Dentistry Post Graduate Resident

Pediatric Dental Resident
UCLA
University Of California, Los Angeles
Los Angeles, California, United States

Co-Author(s)

MM

Megan Maher-Sandstrom, DMD

University of California, Los Angeles

Program Director(s)

Ghassem Ansari, D.D.S., M.Sc, Ph. D., A.P.P.D. (he/him/his)

Clinical Professor
University of California, Los Angeles
UCLA School of Dentistry
Los Angeles, California, United States

Abstract: To evaluate whether a single application of Curodont Repair (P11-4) prevents progression of incipient caries in permanent teeth beyond the dentinoenamel junction (DEJ) and reduces the need for restorative treatment in pediatric patients. This prospective, single-arm longitudinal study enrolled 10 patients aged 6–17 years with at least one incipient permanent-tooth lesion confined to enamel or the DEJ. Each eligible lesion received a single standardized Curodont application at baseline. Follow-up visits will occur at 3, 6, 12, 18, and 24 months which includes visual-tactile examination, standardized intraoral photography, and bitewing radiographs when indicated. The preliminary results will be presented after a 6 month follow up. Lesion severities are assessed clinically using the International Caries Detection and Assessment System (ICDAS) and radiographically by lesion depth relative to the DEJ. Changes in lesion size and depth are determined by comparing serial photographs and radiographs. Examiners are calibrated and blinded to treatment. Primary outcomes include progression into dentin or need for restorative treatment. Secondary outcomes include lesion arrest, radiographic progression, and adverse events. Three-month data are analyzed descriptively to determine the proportion of lesions that remain stable, arrest, or progress based on ICDAS scores and radiographic criteria. It is hypothesized that approximately 80% of lesions will remain stable or arrested at three months. Curodont may provide a minimally invasive option for managing early carious lesions in permanent teeth and reducing the need for restorative treatment in pediatric patients.

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