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Special Health Care Needs

38 - Validated Oral Health Indices in Bone Marrow Failure Syndromes

Friday, May 22, 2026
11:00 AM - 11:15 AM PST
Has Audio

    Presenting Author(s)

  • Chintan Thakore, DMD

    Second Year Pediatric Dental Resident
    Cincinnati Children’s Medical Center Hospital, Cincinnati, OH
    Cincinnati Children's Hospital Medical Center
    Cincinnati, Ohio, United States

    • Co-Author(s)

  • PM

    Parinda Mehta, MD (she/her/hers)

    Professor, Division of BMT and Immune Deficiency
    Cincinnati Children’s Medical Center Hospital, Cincinnati, OH
    Cincinnati Children’s Medical Center Hospital, Cincinnati, OH
    Cincinnati , Ohio, United States

  • Sarat Thikkurissy, DDS, MS, MA (he/him/his)

    Professor
    Cincinnati Children's Hospital
    Cincinnati, Ohio, United States

    • Research Mentor(s)

  • Sarat Thikkurissy, DDS, MS, MA (he/him/his)

    Professor
    Cincinnati Children's Hospital
    Cincinnati, Ohio, United States

    • Program Director(s)

  • Scott Schwartz, DDS, MPH

    Associate Professor
    Cincinnati Children’s Medical Center Hospital, Cincinnati, OH
    Cincinnati Children's Hospital Medical Center
    Cincinnati, Ohio, United States

Abstract:


Purpose: The National Cancer Institute defines inherited bone marrow failure syndromes (IBMFS) as a group of rare genetic blood disorders in which there is some form of aplastic anemia (failure of the bone marrow to produce blood). Conditions under this umbrella term include; Fanconi Anemia, Schwachman-Diamond Syndrome, Dyskeratosis Congenita, and Telomere Biology Disorders. The goal of this study is to describe oral characteristics of patients with inherited bone marrow failures using standardized oral indices to look for oral disease state. This will inform how clinical preventive recommendations can be structured to best serve this population.



Methods: This IRB-approved case cohort study involved assessment of patients with IBMFS by two calibrated examiners using; Simplified Oral Health Index (OHI-S), Modified Gingival Index (MGI), The Ulcer Severity Score (USS/OMAS) and a Mean Oral Erythema score. Clinically visible dental carious lesions were also recorded.



Results: Data were collected from 22 subjects with a mean age of 17.1±5.6 years. Seventy-one percent of patients had a diagnosis of Fanconi Anemia, with 14% having Dyskeratosis Congenita. Mean scores included OHI-S (0.93±0.54), MGI (0.99±0.59), and OMAS ( < 0.04±0.10). Patients had a mean caries score of 0.77±1.2, indicative of 1-3 teeth with clinical caries. One outlier had non-restorable caries along with the highest OHI-S and MGI scores.



Conclusions: Assessed patients’ scores averaged good-to-fair oral hygiene with low-to-moderate gingival inflammation recorded. Development based recommendations from dental home should be followed.

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