28 - Pupil Size Changes as an Objective Indicator of Sedation Depth and Behavior

Abstract:

Purpose: The purpose of this study was to examine the relationship among sedation level, pupil size, and Frankl score, and determine if a simple physiological measure (pupil size change) can enhance behavioral prediction and guide clinical decision-making.

Methods: Thirty-two children received morphine (0.5mg/kg) & Atarax (25mg) and the extent of pupil change, pre-operatively and after medication administration, was measured (via Microsoft PowerPoint) and compared. Sedation depth was documented and a Frankl behavior score was assigned to each patient. Data was analyzed using a regression analysis and ANOVA test.

Results: Thirty-one pediatric patients (55% females, 45% males) were included in the study. An increased depth of sedation was significantly associated with larger changes in pupil size (p < 0.05). Changes in pupil size also differed significantly across Frankl behavior groups (p < 0.05). Patients exhibiting a larger change in pupil size demonstrated higher Frankl scores.

Conclusion: These findings suggest that pupil size may serve as an objective biomarker for both sedation depth and behavioral response.

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