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Oral Pathology

320 - Oropharyngeal Cancer Burden: Disparities by Gender and Region in 2022

Saturday, May 23, 2026
12:30 PM - 12:45 PM PST
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    Presenting Author(s)

  • Alan C. Truong, DMD

    Pediatric Dental Resident (PGY-2)
    NYU Langone
    NYU Langone Dental Medicine, Phoenix, AZ
    Glendale, Arizona, United States

    • Program Director(s)

  • SA

    Shreekrishna Akilesh, DMD

    Program Director
    NYU Langone
    Columbia, Missouri, United States

Abstract:



Purpose: This study examined global patterns and burden of oropharyngeal cancer (OPC) incidence, mortality, and prevalence by region and gender using GLOBOCAN 2022 data to highlight needs for targeted resource allocation, prevention strategies, and improved health equity.

Methods: Data for OPC were extracted from the GLOBOCAN 2022 database and stratified by gender and region. Absolute case counts for incidence, mortality, and five-year prevalence were analyzed to characterize regional disparities and gender differences. Mortality-to-incidence ratios (MIR) were calculated by dividing mortality by incidence for each region and gender, as a proxy for survival.

Results: In 2022, there were 106,400 new OPC cases and 52,305 deaths worldwide. Asia carried the heaviest burden with 47,021 cases (44% of global incidence) and 27,987 deaths (54% of global mortality). Regional MIR varied: Asia (0.60), Africa (0.57), LAC (0.56), Europe (0.44), Oceania (0.29), and North America (0.25). Men had a higher burden, with male-to-female prevalence ratios ranging from 3:1 in Africa to 6:1 in Oceania. However, global MIR was comparable between genders (male: 0.50; female: 0.47), suggesting that disparity reflects differential risk factor exposure rather than survival differences.

Conclusions: OPC global burden varies significantly by region, with MIR ranging from 0.25 to 0.60, reflecting disparities in healthcare access and treatment. While men bear 3 to 6 times higher prevalence, similar MIR between genders suggests this gap reflects risk factor exposure rather than prognosis. Closing these gaps requires expanding gender-neutral HPV vaccination, strengthening tobacco and alcohol prevention, and improving care access in low- and middle- income countries.





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